Clinical score and TEWL were more improved after treatment with TA, whereas the lamellar bodies were more normal after treatment with PIM. An increase in lamellar bodies also occurred with TA treatment (46% p<0.05) however, significantly less than with PIM (p<0.05). A significantly higher number of normal lamellar bodies was found after 3 weeks of treatment with PIM (58% p<0.005). The TEM revealed a strong reduction in lamellar bodies in lesional skin of AD only 32% of the lamellar bodies were normal. The pEASi was significantly more improved with TA compared with PIM, whereas stratum corneum hydration was slightly more improved after treatment with PIM. Bayview Pharmacy is your compounding pharmacy of choice for Hydroquinone 6/Tretinoin 0.04/Triamcinolone Acetonide 0.025 Topical Cream. Partial Eczema Area and Severity Index (pEASi), stratum corneum hydration, and transepidermal water loss (TEWL) were monitored on days 1, 8 and 22. In punch biopsies, before and after treatment, skin lipid bilayer and lamellar body structure were examined by transmission electron microscopy (TEM). In a controlled, randomized, double-blinded, right–left comparison study we investigated the effect of pimecrolimus (PIM) cream compared with triamcinolone acetonide cream (TA) on the skin barrier in 15 patients with symmetrical elbow lesions of AD. Stratum corneum skin barrier is formed by corneocytes and extracellular lipids extruded from the epidermal lamellar bodies. Patients with atopic dermatitis (AD) have an epidermal barrier dysfunction, which allows invasion of allergens to occur.
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